abstract：:Closed-head concussive injury is one of the most common causes of traumatic brain injury (TBI). While single concussions result in short-term neurologic dysfunction, multiple concussions can result in cumulative damage and increased risk for neurodegenerative disease. Despite the prevalence of concussion, knowledge ab...

journal_title：Journal of neurotrauma

authors： Chen Z,Leung LY,Mountney A,Liao Z,Yang W,Lu XC,Dave J,Deng-Bryant Y,Wei G,Schmid K,Shear DA,Tortella FC

更新日期：2012-01-20 00:00:00

abstract：:Guidelines for patients with severe traumatic brain injury (sTBI) published in 2007 recommend providing early nutrition after trauma. Early enteral nutrition (EN) started within 48 h post-injury reduces clinical malnutrition, prevents bacterial translocation from the gastrointestinal tract, and improves outcome in sTB...

journal_title：Journal of neurotrauma

authors： Chiang YH,Chao DP,Chu SF,Lin HW,Huang SY,Yeh YS,Lui TN,Binns CW,Chiu WT

更新日期：2012-01-01 00:00:00

abstract：:This prospective multicenter study investigated the association of the course of coagulation abnormalities with initial computed tomography (CT) characteristics and outcome in patients with isolated traumatic brain injury (TBI). Patient demographics, coagulation parameters, CT characteristics, and outcome data of mode...

journal_title：Journal of neurotrauma

authors： Franschman G,Boer C,Andriessen TM,van der Naalt J,Horn J,Haitsma I,Jacobs B,Vos PE

更新日期：2012-01-01 00:00:00

abstract：:Predicting outcome after pediatric traumatic brain injury (TBI) is important for providing information to families and prescribing rehabilitation services. Previously published studies evaluating the ability of serum biomarkers to predict outcome after pediatric TBI have focused on three markers: neuron-specific enola...

journal_title：Journal of neurotrauma

authors： Berger RP,Hayes RL,Richichi R,Beers SR,Wang KK

更新日期：2012-01-01 00:00:00

abstract：:The etiology of multiple sclerosis (MS) is still not well known. Previous data show conflicting results regarding the association between MS and prior brain trauma. This study aims to investigate the risk for MS following a traumatic brain injury (TBI) using a large-scale cohort study design. This study used data from...

journal_title：Journal of neurotrauma

authors： Kang JH,Lin HC

更新日期：2012-01-01 00:00:00

abstract：:Spinal cord injury damaging the rubrospinal tract (RST) interferes with skilled forelimb movement, but identification of the precise role of the RST in this behavior is impeded by the difficulty of surgically isolating the RST from other pathways running within the lateral funiculus (LF). The present study used a skil...

journal_title：Journal of neurotrauma

authors： Morris R,Tosolini AP,Goldstein JD,Whishaw IQ

更新日期：2011-12-01 00:00:00

abstract：:Cytokine measurement directly from the brain parenchyma by means of microdialysis has documented the activation of certain procedures in vivo, after brain trauma in humans. However, the intercalation of the micro-catheter insertion with the phenomena triggered by the head trauma renders the assessment of the findings ...

journal_title：Journal of neurotrauma

authors： Bouras TI,Gatzonis SS,Georgakoulias N,Karatza M,Sianouni A,Stranjalis G,Boviatsis E,Vasileiou S,Sakas DE

更新日期：2011-11-18 00:00:00

abstract：:Microarray-based transcriptional profiling was used to determine the effect of progesterone in the cortical contusion (CCI) model. Gene ontology (GO) analysis then evaluated the effect of dose on relevant biological pathways. Treatment (vehicle, progesterone 10 mg/kg or 20 mg/kg given i.p.) was started 4 h post-injury...

journal_title：Journal of neurotrauma

authors： Anderson GD,Farin FM,Bammler TK,Beyer RP,Swan AA,Wilkerson HW,Kantor ED,Hoane MR

更新日期：2011-09-01 00:00:00

abstract：:Strategies aimed at improving spinal cord regeneration after trauma are still challenging neurologists and neuroscientists throughout the world. Many cell-based therapies have been tested, with limited success in terms of functional outcome. In this study, we investigated the effects of human dental pulp cells (HDPCs)...

journal_title：Journal of neurotrauma

authors： de Almeida FM,Marques SA,Ramalho Bdos S,Rodrigues RF,Cadilhe DV,Furtado D,Kerkis I,Pereira LV,Rehen SK,Martinez AM

更新日期：2011-09-01 00:00:00

abstract：:Traumatic brain injury (TBI) induces transient or persistent dysfunction of gait and balance. Enhancement of cholinergic transmission has been reported to accelerate recovery of cognitive function after TBI, but the effects of this intervention on locomotor activity remain largely unexplored. The hypothesis that enhan...

journal_title：Journal of neurotrauma

authors： Holschneider DP,Guo Y,Roch M,Norman KM,Scremin OU

更新日期：2011-09-01 00:00:00

abstract：:An increasing number of therapies for spinal cord injury (SCI) are emerging from the laboratory and seeking translation into human clinical trials. Many of these are administered as soon as possible after injury with the hope of attenuating secondary damage and maximizing the extent of spared neurologic tissue. In thi...

journal_title：Journal of neurotrauma

authors： Kwon BK,Okon EB,Plunet W,Baptiste D,Fouad K,Hillyer J,Weaver LC,Fehlings MG,Tetzlaff W

更新日期：2011-08-01 00:00:00

abstract：:A systematic review of the literature was performed to address pertinent clinical questions regarding deep vein thrombosis (DVT) prophylaxis in the setting of acute spinal cord injury (SCI). Deep vein thromboses are a common occurrence following SCI. Administration of low-molecular-weight heparin (LMWH) within 72 h of...

journal_title：Journal of neurotrauma

authors： Christie S,Thibault-Halman G,Casha S

更新日期：2011-08-01 00:00:00

abstract：:This study examines the effects of combination therapy of collagen scaffolds and human marrow stromal cells (hMSCs) on the expression of tissue plasminogen activator (tPA) after traumatic brain injury (TBI) in rats. Adult male Wistar rats (n=48) were injured with controlled cortical impact and treated either with scaf...

journal_title：Journal of neurotrauma

authors： Mahmood A,Qu C,Ning R,Wu H,Goussev A,Xiong Y,Irtenkauf S,Li Y,Chopp M

更新日期：2011-07-01 00:00:00

abstract：:Although chronic sleepiness is common after head trauma, the cause remains unclear. Transcranial magnetic stimulation (TMS) represents a useful complementary approach in the study of sleep pathophysiology. We aimed to determine in this study whether post-traumatic sleep-wake disturbances (SWD) are associated with chan...

journal_title：Journal of neurotrauma

authors： Nardone R,Bergmann J,Kunz A,Caleri F,Seidl M,Tezzon F,Gerstenbrand F,Trinka E,Golaszewski S

更新日期：2011-07-01 00:00:00

abstract：:Concussive brain injury (CBI) accounts for approximately 75% of all brain-injured people in the United States each year and is particularly prevalent in contact sports. Concussion is the mildest form of diffuse traumatic brain injury (TBI) and results in transient cognitive dysfunction, the neuropathologic basis for w...

journal_title：Journal of neurotrauma

authors： Creed JA,DiLeonardi AM,Fox DP,Tessler AR,Raghupathi R

更新日期：2011-04-01 00:00:00

abstract：:Symptoms persisting beyond the acute phase (>2 months) after a mild traumatic brain injury (MTBI) are often reported, but their origin remains controversial. Some investigators evoke dysfunctional cerebral mechanisms, while others ascribe them to the psychological consequences of the injury. We address this controvers...

journal_title：Journal of neurotrauma

authors： Gosselin N,Bottari C,Chen JK,Petrides M,Tinawi S,de Guise E,Ptito A

更新日期：2011-03-01 00:00:00

abstract：:Outcome of traumatic brain injury (TBI) is impaired by hyperglycemia, hypotension, and glutamate, and improved by insulin. Insulin reduces glutamate concentration, making it uncertain whether its beneficial effect accrues from euglycemia. Glucagon decreases CNS glutamate, lessens neuronal cell injury, and improves neu...

journal_title：Journal of neurotrauma

authors： Armstead WM,Kiessling JW,Cines DB,Higazi AA

更新日期：2011-03-01 00:00:00

abstract：:Collaboration among investigators, centers, countries, and disciplines is essential to advancing the care for traumatic brain injury (TBI). It is thus important that we "speak the same language." Great variability, however, exists in data collection and coding of variables in TBI studies, confounding comparisons betwe...

journal_title：Journal of neurotrauma

authors： Maas AI,Harrison-Felix CL,Menon D,Adelson PD,Balkin T,Bullock R,Engel DC,Gordon W,Langlois-Orman J,Lew HL,Robertson C,Temkin N,Valadka A,Verfaellie M,Wainwright M,Wright DW,Schwab K

更新日期：2011-02-01 00:00:00

abstract：:Acupressure is a complementary and alternative medicine (CAM) treatment using fingertips to stimulate acupoints on the skin. Although suggested to improve cognitive function, acupressure has not been previously investigated with a controlled design in traumatic brain injury (TBI) survivors, who could particularly bene...

journal_title：Journal of neurotrauma

authors： McFadden KL,Healy KM,Dettmann ML,Kaye JT,Ito TA,Hernández TD

更新日期：2011-01-01 00:00:00

abstract：:Posttraumatic amnesia (PTA) is a common symptom following traumatic brain injury. Although this transient memory deficit implies specific impairment of higher brain function, the actual pathophysiology of PTA is not well understood. The aim of this study was to assess regional cerebral hemodynamics with perfusion comp...

journal_title：Journal of neurotrauma

authors： Metting Z,Rödiger LA,de Jong BM,Stewart RE,Kremer BP,van der Naalt J

更新日期：2010-12-01 00:00:00

abstract：:We investigated the effect of sports activity on physically-disabled individuals using behavioral and electrophysiological techniques. Visual go/no-go discriminative and simple response tasks were used. Participants included 17 disabled athletes, 9 from open-skill (wheelchair basketball) and eight from closed-skill (s...

journal_title：Journal of neurotrauma

authors： Di Russo F,Bultrini A,Brunelli S,Delussu AS,Polidori L,Taddei F,Traballesi M,Spinelli D

更新日期：2010-12-01 00:00:00

abstract：:Traumatic injury to the central nervous system (CNS) is accompanied by the spreading damage of secondary degeneration, resulting in further loss of neurons and function. Partial transection of the optic nerve (ON) has been used as a model of secondary degeneration, in which axons of retinal ganglion cells in the ventr...

journal_title：Journal of neurotrauma

authors： Fitzgerald M,Bartlett CA,Payne SC,Hart NS,Rodger J,Harvey AR,Dunlop SA

更新日期：2010-11-01 00:00:00

abstract：:Diagnosis and treatment of stroke and traumatic brain injury remain significant health care challenges to society. Patient care stands to benefit from an improved understanding of the interactive biochemistry underlying neurotrauma pathobiology. In this study, we assessed the power of neuroproteomics to contrast bioch...

journal_title：Journal of neurotrauma

authors： Ottens AK,Bustamante L,Golden EC,Yao C,Hayes RL,Wang KK,Tortella FC,Dave JR

更新日期：2010-10-01 00:00:00

abstract：:Reactive oxygen species have been implicated in the pathogenesis of hypoxic-ischemic injury. It has been shown previously that treating an animal with N-acetyl-L-cysteine (NAC), a scavenger of free radicals, significantly minimizes hypoxic-ischemic-induced brain injury in various acute models. Using a subacute swine m...

journal_title：Journal of neurotrauma

authors： Liu JQ,Lee TF,Chen C,Bagim DL,Cheung PY

更新日期：2010-10-01 00:00:00

abstract：:To compare the effect of levodopa-carbidopa on the visual outcome of patients with indirect traumatic optic neuropathy (ITON), this randomized, double-blind, placebo-controlled study was conducted on 32 patients with ITON within 6 days after trauma. Patients underwent a complete ocular examination, pattern visual evok...

journal_title：Journal of neurotrauma

authors： Razeghinejad MR,Rahat F,Bagheri M

更新日期：2010-10-01 00:00:00

abstract：:Neuropathic pain and motor deficits are detrimental consequences of injury to the spinal cord. In experimental settings, numerous neuroprotective agents are being explored for their therapeutic benefits. Vascular endothelial growth factor (VEGF) is an interesting candidate molecule in this respect since it is not only...

journal_title：Journal of neurotrauma

authors： van Neerven S,Joosten EA,Brook GA,Lambert CA,Mey J,Weis J,Marcus MA,Steinbusch HW,van Kleef M,Patijn J,Deumens R

更新日期：2010-10-01 00:00:00

abstract：:Penetrating ballistic brain injury involves a leading shockwave producing a temporary cavity causing substantial secondary injury. In response to the prevalence of this type of brain trauma in the military, a rat model of penetrating ballistic-like brain injury (PBBI) was established. This study focuses on cerebral ph...

journal_title：Journal of neurotrauma

authors： Wei G,Lu XC,Yang X,Tortella FC

更新日期：2010-09-01 00:00:00

abstract：:Spinal cord injury (SCI) leading to neurological deficits produces long-term effects that persist over a lifetime. Survival analysis of patients with SCI, at individual and population level, is important for public health management and the assessment of treatment achievements. The current study evaluated survival fol...

journal_title：Journal of neurotrauma

authors： van den Berg ME,Castellote JM,de Pedro-Cuesta J,Mahillo-Fernandez I

更新日期：2010-08-01 00:00:00

abstract：:Traumatic brain injury (TBI) is one of the most acute degenerative pathologies in the central nervous system, and in vivo indices enabling an assessment of TBI on a mechanistic basis have yet to be established. The aim of this work was to pursue neuroinflammatory changes and their link to functional disruptions of tra...

journal_title：Journal of neurotrauma

authors： Yu I,Inaji M,Maeda J,Okauchi T,Nariai T,Ohno K,Higuchi M,Suhara T

更新日期：2010-08-01 00:00:00

abstract：:Gap junctions are conductive channels formed by membrane proteins termed connexins (Cx), which permit the intercellular exchange of metabolites, ions, and small molecules. Junctional permeability is regulated by pH, membrane potential, and intracellular secondary messengers. The purpose of this study was to elucidate ...

journal_title：Journal of neurotrauma

authors： Ohsumi A,Nawashiro H,Otani N,Ooigawa H,Toyooka T,Shima K

更新日期：2010-07-01 00:00:00

abstract：:Functional recovery is markedly restricted following traumatic brain injury (TBI), partly due to myelin-associated inhibitors including Nogo-A, myelin-associated glycoprotein (MAG) and oligodendrocyte myelin glycoprotein (OMgp), that all bind to the Nogo-66 receptor-1 (NgR1). In previous studies, pharmacological neutr...

journal_title：Journal of neurotrauma

authors： Hånell A,Clausen F,Björk M,Jansson K,Philipson O,Nilsson LN,Hillered L,Weinreb PH,Lee D,McIntosh TK,Gimbel DA,Strittmatter SM,Marklund N

更新日期：2010-07-01 00:00:00

abstract：:Considerable effort and resources have been devoted to preserving life in patients with severe closed traumatic brain injury (TBI). We sought to identify temporal trends in mortality rates of these patients from the late 1800s to the present. We searched the literature for articles on severe TBI, abstracting numbers o...

journal_title：Journal of neurotrauma

authors： Stein SC,Georgoff P,Meghan S,Mizra K,Sonnad SS

更新日期：2010-07-01 00:00:00

abstract：:Fatalities or injuries following motorized and non-motorized vehicle accidents (MNMVA) are reported by police or health care systems. However, limited data exist for spinal injuries. Using an epidemiological database of road accidents occurring in a defined geographic area, we measured the incidence of major spinal tr...

journal_title：Journal of neurotrauma

authors： Lieutaud T,Ndiaye A,Frost F,Chiron M,Registry Group.

更新日期：2010-06-01 00:00:00

abstract：:Chronic pain and dysesthesias are debilitating conditions that can arise following spinal cord injury (SCI). Research studies frequently employ rodent models of SCI to better understand the underlying mechanisms and develop better treatments for these phenomena. While evoked withdrawal tests can assess hypersensitivit...

journal_title：Journal of neurotrauma

authors： Hoschouer EL,Finseth T,Flinn S,Basso DM,Jakeman LB

更新日期：2010-05-01 00:00:00

abstract：:There is an urgent need for both the scientific development and clinical validation of novel therapies for acute spinal cord injury (SCI). The scientific development of novel therapies would be facilitated by a better understanding of the acute pathophysiology of human SCI. Clinical validation of such therapies would ...

journal_title：Journal of neurotrauma

authors： Kwon BK,Stammers AM,Belanger LM,Bernardo A,Chan D,Bishop CM,Slobogean GP,Zhang H,Umedaly H,Giffin M,Street J,Boyd MC,Paquette SJ,Fisher CG,Dvorak MF

更新日期：2010-04-01 00:00:00

abstract：:Recovery of fine motor skills after traumatic brain injury (TBI) is variable, with some patients showing progressive improvements over time while others show poor recovery. We therefore studied possible cellular mechanisms accompanying the recovery process in a non-human primate model system, in which the lateral fron...

journal_title：Journal of neurotrauma

authors： Nagamoto-Combs K,Morecraft RJ,Darling WG,Combs CK

更新日期：2010-03-01 00:00:00

abstract：:Diffuse axonal injury (DAI) secondary to traumatic brain injury (TBI) contributes to long-term functional morbidity. The corpus callosum (CC) is particularly vulnerable to this type of injury. Magnetic resonance spectroscopy (MRS) was used to characterize the metabolic status of two CC regions of interest (ROIs) (ante...

journal_title：Journal of neurotrauma

authors： Babikian T,Marion SD,Copeland S,Alger JR,O'Neill J,Cazalis F,Mink R,Giza CC,Vu JA,Hilleary SM,Kernan CL,Newman N,Asarnow RF

更新日期：2010-03-01 00:00:00

abstract：:Since free radicals play a role in the mechanisms of brain injury after hemorrhagic stroke, the effect of melatonin (a potent antioxidant and free-radical scavenger) on outcomes was investigated after intracerebral hemorrhage (ICH) in rats. ICH was induced by clostridial collagenase infusion into the right caudate put...

journal_title：Journal of neurotrauma

authors： Lekic T,Hartman R,Rojas H,Manaenko A,Chen W,Ayer R,Tang J,Zhang JH

更新日期：2010-03-01 00:00:00

abstract：:Hearing impairment can be one of the more subtle deficits seen after closed head injury (CHI), and it may not be diagnosed until late in the recovery phase if at all. Most studies have assessed patients immediately after CHI. Repeated assessments at regular intervals were not performed in the majority of studies done ...

journal_title：Journal of neurotrauma

authors： Munjal SK,Panda NK,Pathak A

更新日期：2010-02-01 00:00:00

abstract：:In this study we investigated regional cerebral glucose metabolism abnormalities of [(18)F] fluorodeoxyglucose (FDG) positron emission tomography (PET) imaging in traumatic brain injury (TBI). PET images of 81 TBI patients and 68 normal controls were acquired and a word list learning task was administered during the u...

journal_title：Journal of neurotrauma

authors： Zhang J,Mitsis EM,Chu K,Newmark RE,Hazlett EA,Buchsbaum MS

更新日期：2010-01-01 00:00:00